Description

(R)-2-(3,5-Difluorophenyl)Piperidine Hydrochloride is a high-purity chiral piperidine derivative, serving as a critical building block in modern pharmaceutical research and development. Its value lies in its role as a versatile synthetic intermediate for creating novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics. This compound is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and advanced fine chemical synthesis industries who require enantiomerically pure intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route scouting for API manufacturing.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in enantioselective synthesis protocols.
• Biochemical Tool Compound: Potential use in the development of receptor ligands and enzyme inhibitors for biological screening.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory filings.

Basic Information

Product Name	(R)-2-(3,5-Difluorophenyl)Piperidine Hydrochloride
CAS No.	2307737-00-2
Molecular Formula	C11H14ClF2N
Molecular Weight	233.69 g/mol
Synonyms	(R)-2-(3,5-Difluorophenyl)piperidine hydrochloride; (R)-2-(3,5-Difluorophenyl)piperidine HCl; (3R)-2-(3,5-Difluorophenyl)piperidinium chloride; (R)-2-(3,5-Difluorophenyl)piperidinium chloride; 2-(3,5-Difluorophenyl)piperidine hydrochloride, (R)-; Piperidine, 2-(3,5-difluorophenyl)-, hydrochloride, (2R)-; (R)-2-(3,5-Difluorophenyl)piperidine monohydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(3,5-Difluorophenyl)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.