Description

tert-Butyl 2-(p-Tolylsulfonyloxymethyl)-6,7-Dihydro-4H-Pyrazolo[1,5-A]Pyrazine-5-Carboxylate CAS NO 2306274-60-0 is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic core. This compound is specifically designed as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical R&D and contract manufacturing organizations (CMOs) for the development of targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for novel drug discovery programs.
• Heterocyclic Compound Synthesis: Serves as a versatile scaffold for constructing complex fused pyrazolo-pyrazine derivatives with potential biological activity.
• Kinase Inhibitor Development: Particularly relevant for the research and development of small molecule kinase inhibitors due to its privileged structural motif.
• Custom Synthesis & Scale-Up: Employed by CROs and CMOs for process development and the production of gram to kilogram quantities for clinical trials.
• Chemical Biology Probes: Can be utilized in the creation of molecular probes for studying specific biological targets and mechanisms.

Basic Information

Product Name	tert-Butyl 2-(p-Tolylsulfonyloxymethyl)-6,7-Dihydro-4H-Pyrazolo[1,5-A]Pyrazine-5-Carboxylate
CAS No.	2306274-60-0
Molecular Formula	C20H25N3O5S
Molecular Weight	419.50 g/mol
Synonyms	tert-Butyl 2-(((4-methylphenyl)sulfonyloxy)methyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylate; 2-((p-Toluenesulfonyloxy)methyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester; 5-tert-Butoxycarbonyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-2-ylmethyl 4-methylbenzenesulfonate; CAS 2306274-60-0; Pyrazolo[1,5-a]pyrazine intermediate; Tosylate-protected pyrazolopyrazine ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications from HPLC, NMR, and mass spectrometry are provided with each shipment. We support development needs with custom purity grades and documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.