Description

tert-Butyl 2-(Chloromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carboxylate is a high-value, advanced pharmaceutical intermediate characterized by its imidazopyrazine core and reactive chloromethyl group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential therapeutic applications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: The reactive chloromethyl moiety can be utilized for attaching fluorescent labels, affinity tags, or other functional groups to biomolecules for research purposes.
• Library Synthesis for High-Throughput Screening: A valuable scaffold for generating diverse compound libraries to identify new biological hits.

Basic Information

Product Name	tert-Butyl 2-(Chloromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carboxylate
CAS No.	2306263-07-8
Molecular Formula	C13H18ClN3O2
Molecular Weight	283.75 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-2-(chloromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazine; 2-(Chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester; tert-Butyl 2-(chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carboxylate; 2306263-07-8; Imidazo[1,2-a]pyrazine-7-carboxylic acid, 2-(chloromethyl)-6,8-dihydro-5H-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Chloromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-7-carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.