Description

2-Piperazinemethanol, 4-(Phenylmethyl)-, Hydrochloride (1:2), (2R)- is a high-purity chiral piperazine derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in its role as a sophisticated intermediate for developing targeted active pharmaceutical ingredients (APIs), particularly in neurological and oncological research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to create novel therapeutic agents with high stereochemical purity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and oncology targets.
• API Synthesis: Serves as a critical building block in the multi-step synthesis of complex, stereochemically-defined active pharmaceutical ingredients.
• Asymmetric Catalysis Research: Used as a ligand precursor or chiral auxiliary in the development of new asymmetric synthetic methodologies.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for cost-effective and reproducible manufacturing of advanced intermediates.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2-Piperazinemethanol, 4-(Phenylmethyl)-, Hydrochloride (1:2), (2R)-
CAS No.	2306249-22-7
Molecular Formula	C12H18N2O · 2HCl
Molecular Weight	295.21 g/mol (Free base: 206.29)
Synonyms	(2R)-4-Benzyl-2-piperazinemethanol Dihydrochloride; (R)-4-Benzyl-2-(hydroxymethyl)piperazine Dihydrochloride; (R)-1-Benzyl-3-(hydroxymethyl)piperazine Dihydrochloride; (2R)-4-Benzylpiperazine-2-methanol Dihydrochloride; 4-Benzyl-(2R)-piperazin-2-ylmethanol Dihydrochloride; (R)-Homo-Bn-Pip Dihydrochloride; Bn-Pip(R)-CH2OH · 2HCl
EINECS	Contact for details

Quality Control

Our 2-Piperazinemethanol, 4-(Phenylmethyl)-, Hydrochloride (1:2), (2R)- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and process development. A detailed Certificate of Analysis (COA) providing full specification results is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.