Description

Propargyl-Peg11-Methane is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group. This compound is engineered for advanced bioconjugation and click chemistry applications, offering a reactive handle for site-specific modification of biomolecules and materials. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality linkers for drug delivery systems, diagnostic probes, and hydrogel synthesis.

Application

• Bioconjugation Linker: Used for the site-specific attachment of drugs, peptides, or fluorescent dyes to antibodies, proteins, and other biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• PEGylation Reagent: Serves as a functional PEG spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic proteins and peptides.
• Polymer & Hydrogel Synthesis: Acts as a cross-linking agent or functional monomer in the creation of biocompatible hydrogels and smart polymers for tissue engineering and controlled release.
• Diagnostic Probe Development: Utilized in the fabrication of diagnostic assays and imaging agents by conjugating targeting ligands to reporter molecules.
• Surface Functionalization: Enables the modification of nanoparticles, chips, and other material surfaces with bio-recognition elements for biosensing and lab-on-a-chip devices.
• Antibody-Drug Conjugate (ADC) Payload Attachment: Provides a stable, cleavable, or non-cleavable linkage for attaching cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	Propargyl-Peg11-Methane
CAS No.	2250411-18-6
Molecular Formula	C26H50O12
Molecular Weight	554.7 g/mol
Synonyms	Propargyl-PEG11-CH3; 3-(2-(2-(2-(2-(2-(2-(2-(2-(2-(2-Methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)prop-1-yne; Propargyl-PEG11-methyl ether; mPEG11-Propargyl; α-Methyl-ω-propargyl-undecaethylene glycol; Propargyl terminated PEG methyl ether (MW ~550); Alkyne-PEG11-OMe; Propargyl-O-(CH2CH2O)11-CH3
EINECS	Contact for details

Quality Control

Our Propargyl-Peg11-Methane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation workflows. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and functional group integrity, supporting compliance with research and cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Average Molecular Weight (GPC)	540 - 570 g/mol
Functional Group Assay (NMR)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.