Description

Mpeg24-Acid CAS NO 2248203-61-2 is a high-purity, monodisperse polyethylene glycol (PEG) derivative functionalized with a terminal carboxylic acid group. This compound is critical for creating stable, biocompatible conjugates in advanced pharmaceutical and biotechnological applications. It is primarily utilized by researchers and manufacturers in drug delivery, bioconjugation, and surface modification who require precise linker chemistry and reliable, reproducible performance.

Application

• Pharmaceutical Conjugation: Acts as a versatile linker for attaching therapeutic agents (e.g., proteins, peptides, small molecule drugs) to carriers like nanoparticles or other polymers.
• PEGylation Reagent: Used to modify biomolecules to enhance solubility, reduce immunogenicity, and prolong circulation half-life in vivo.
• Surface Functionalization: Employed to introduce carboxyl groups onto material surfaces (e.g., gold nanoparticles, quantum dots, medical devices) for subsequent covalent bonding.
• Crosslinking Agent: Serves as a hydrophilic spacer in the synthesis of hydrogels, polymer networks, and diagnostic reagents.
• Intermediate for Further Derivatization: The carboxylic acid group can be readily activated to form esters or amides, enabling the synthesis of a wide array of custom PEG derivatives.
• Biomaterial Fabrication: Incorporated into scaffolds and matrices to improve biocompatibility and control drug release profiles.

Basic Information

Product Name	Mpeg24-Acid
CAS No.	2248203-61-2
Molecular Formula	Contact for details
Molecular Weight	~1100 g/mol (for 24 EO units)
Synonyms	mPEG24-Acid; Methoxy-PEG24-carboxylic acid; α-Methoxy-ω-carboxy-poly(ethylene glycol); mPEG24-COOH; PEG methyl ether carboxylic acid (n~24); Monomethoxy polyethylene glycol carboxylic acid (24 EO); 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid (oligomer); Poly(ethylene glycol) methyl ether carboxyl-terminated
EINECS	Contact for details

Quality Control

Our Mpeg24-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and titration, to ensure high purity and consistent molecular weight distribution. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and cGMP-grade application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Molecular Weight (NMR)	1100 ± 50 g/mol
Polydispersity Index (PDI)	≤ 1.05
Acid Value (Titration)	50 - 55 mg KOH/g
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.