Description

1-Propanone, 1-[5-[(2,3-Dihydro-1,4-Dioxino[2,3-B]Pyridin-7-Yl)Sulfonyl]-3,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrrol-2(1H)-Yl]-3-Hydroxy-2-Phenyl-, (2S)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique fused ring system.
• Protease Inhibitor Development: Serves as a core scaffold for the development of inhibitors targeting specific enzymes.
• Bioconjugation & Probe Synthesis: Utilized in creating chemical probes for biological target identification and validation in early-stage drug discovery.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	1-Propanone, 1-[5-[(2,3-Dihydro-1,4-Dioxino[2,3-B]Pyridin-7-Yl)Sulfonyl]-3,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrrol-2(1H)-Yl]-3-Hydroxy-2-Phenyl-, (2S)-
CAS No.	2245053-57-8
Molecular Formula	C24H25N3O6S
Molecular Weight	483.54 g/mol
Synonyms	(2S)-1-[5-[(2,3-Dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)sulfonyl]-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-3-hydroxy-2-phenylpropan-1-one; (2S)-1-(5-((2,3-Dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)sulfonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one; 7-[(2S)-2-(3-Hydroxy-2-phenylpropanoyl)octahydropyrrolo[3,4-c]pyrrol-5-yl]sulfonyl-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; Advanced Heterocyclic Sulfonamide Intermediate; Fused Pyrrolo-Pyridine Sulfone Derivative
EINECS	Contact for details

Quality Control

Our 1-Propanone, 1-[5-[(2,3-Dihydro-1,4-Dioxino[2,3-B]Pyridin-7-Yl)Sulfonyl]-3,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrrol-2(1H)-Yl]-3-Hydroxy-2-Phenyl-, (2S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade and cGMP standards for pharmaceutical development. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.