Description

Ho-Peg24-Oh CAS NO 2243942-52-9 is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a hydroxyl group at each terminus of a precisely defined 24-unit PEG chain. This bifunctional PEG linker is critical for creating stable, biocompatible conjugates and modifying biomolecules to enhance their solubility and pharmacokinetic properties. It is an essential building block for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require precise control over molecular architecture and consistent batch-to-batch performance.

Application

• Pharmaceutical Conjugation: Used as a linker for PEGylating peptides, proteins, and oligonucleotides to improve stability, reduce immunogenicity, and prolong circulation half-life.
• Bioconjugation Reagent: Serves as a spacer or crosslinker in the development of antibody-drug conjugates (ADCs), diagnostic probes, and biosensors.
• Hydrogel Synthesis: Acts as a key monomer or crosslinking agent in the fabrication of biocompatible hydrogels for drug delivery and tissue engineering.
• Surface Modification: Employed to create hydrophilic, protein-resistant coatings on nanoparticles, medical devices, and diagnostic platforms.
• Polymer Chemistry: Functions as a macroinitiator or building block for synthesizing block copolymers and functionalized polymeric materials.
• Material Science: Utilized in the development of non-fouling surfaces, smart materials, and controlled-release systems.

Basic Information

Product Name	Ho-Peg24-Oh
CAS No.	2243942-52-9
Molecular Formula	C48H98O25
Molecular Weight	~1123.3 g/mol
Synonyms	α,ω-Dihydroxypoly(ethylene glycol); 24-Mer PEG diol; Poly(ethylene glycol) bis(hydroxy) (n=24); PEG 24 diol; 1,1'-[1,2-ethanediylbis(oxy)]bis-24-hydroxytetracosa-1-ol (theoretical IUPAC); HO-PEG24-OH; Bifunctional PEG 24; Polyoxyethylene bis(hydroxy) (24 EO units)
EINECS	Contact for details

Quality Control

Our Ho-Peg24-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, precise molecular weight, and consistent functionality. Certificates of Analysis (COA) are provided, detailing specifications for identity, assay, polydispersity, and critical impurities. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Molecular Weight (SEC)	1100 - 1150 g/mol
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.