Description

2-(3-Aminopropyl)-3-[[(1,1-Dimethylethyl)'Dimethylsilyl]'Oxy]-1,1-Dimethylethyl'Ester,'(2R,3S)-1-Piperidinecarboxylic'Acid is a sophisticated chiral building block and protected intermediate of significant interest in advanced organic synthesis. This compound is engineered to provide chemists with a versatile handle for constructing complex molecules with precise stereochemical control. It is primarily utilized by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly in medicinal chemistry programs.
• Peptidomimetic Research: Used to introduce constrained piperidine carboxylic acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a building block for creating complex, enantiomerically pure molecules for catalysis and material science applications.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) protecting group allows for selective deprotection in complex synthetic routes.
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis: Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	2-(3-Aminopropyl)-3-[[(1,1-Dimethylethyl)'Dimethylsilyl]'Oxy]-1,1-Dimethylethyl'Ester,'(2R,3S)-1-Piperidinecarboxylic'Acid
CAS No.	2241812-39-3
Molecular Formula	C20H41NO4Si
Molecular Weight	387.64 g/mol
Synonyms	(2R,3S)-1-[(3-Aminopropyl)-3-(tert-butyldimethylsilyloxy)-2,2-dimethylpropyl]piperidine-1-carboxylate; (2R,3S)-1-Piperidinecarboxylic Acid 2-(3-Aminopropyl)-3-[(tert-Butyldimethylsilyl)oxy]-2,2-dimethylethyl Ester; TBDMS-protected (2R,3S)-Piperidinecarboxylate Aminopropyl Ester; (2R,3S)-N-[(3-Aminopropyl)-3-(TBDMS-oxy)-2,2-dimethylpropyl]piperidine-1-carboxamide precursor; CAS 2241812-39-3
EINECS	Contact for details

Quality Control

Our 2-(3-Aminopropyl)-3-[[(1,1-Dimethylethyl)'Dimethylsilyl]'Oxy]-1,1-Dimethylethyl'Ester,'(2R,3S)-1-Piperidinecarboxylic'Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.