Description

Amino-Peg36-Acid CAS NO 2241751-76-6 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a carboxylic acid group at the other, separated by a 36-unit PEG spacer. This bifunctionality is critical for creating stable, hydrophilic linkers in bioconjugation, enabling the coupling of biomolecules, drugs, or surfaces with precise control over orientation and spacing. It is an essential reagent for researchers and manufacturers in pharmaceutical development, diagnostics, and advanced material science, particularly for constructing antibody-drug conjugates (ADCs), peptide modifications, and functionalized nanoparticles.

Application

• Bioconjugation and Linker Chemistry: A key building block for creating cleavable or non-cleavable linkers in Antibody-Drug Conjugates (ADCs) and other targeted therapeutics.
• PEGylation Reagent: Used to modify peptides, proteins, and oligonucleotides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Surface Functionalization: For introducing amine or carboxyl groups onto nanoparticles, quantum dots, biosensors, and chromatography matrices to enable further coupling.
• Crosslinking Agent: Facilitates the formation of hydrogels, polymer networks, and biomaterial scaffolds with controlled physicochemical properties.
• Diagnostic Probe Synthesis: Employed in the development of fluorescent probes, MRI contrast agents, and other imaging tools by linking targeting moieties to signal molecules.
• Drug Delivery Systems: Integral in designing dendrimers, micelles, and liposomal formulations for controlled and targeted drug release.

Basic Information

Product Name	Amino-Peg36-Acid
CAS No.	2241751-76-6
Molecular Formula	C74H149N1O38
Molecular Weight	~1684.0 g/mol
Synonyms	NH2-PEG36-COOH; α-Amino-ω-carboxy hexatriaconta(ethylene glycol); 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86,89,92,95,98,101,104,107-Triacontaoxanonatriacontanedioic acid, 110-amino-; 19-Aza-4,7,10,13,16,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82,85,88,91,94,97,100,103,106,109,112-hexatriacontaoxanonatriacontanedioic acid; Amine-PEG36-Acid; Heterobifunctional PEG 36, amine and acid.
EINECS	Contact for details

Quality Control

Every batch of Amino-Peg36-Acid is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure high purity and batch-to-batch consistency. Our products are suitable for research and GMP-grade applications. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as purity (HPLC/NMR), functional group substitution, and molecular weight distribution.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight (NMR/SEC)	~1684.0 g/mol (by end-group analysis)
Amine Substitution	≥ 90%
Acid Substitution	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.