Description

3-(Aminomethyl)Bicyclo[1.1.1]Pentane-1-Carbonitrile Hydrochloride is a high-value, structurally constrained bicyclic building block featuring a rigid [1.1.1]propellane core. This compound is essential for medicinal chemistry research and development, offering a unique three-dimensional scaffold to modulate the physicochemical properties of drug candidates. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the rigid bicyclo[1.1.1]pentane (BCP) motif into drug molecules to improve metabolic stability, solubility, and permeability.
• Medicinal Chemistry: Used in fragment-based drug discovery and lead optimization to explore novel chemical space and replace traditional aromatic or aliphatic rings.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker component due to its defined geometry and functional handles (amine and nitrile groups).
• Agrochemical Research: Employed in the synthesis of novel active ingredients with potentially enhanced efficacy and environmental profiles.
• Material Science: Investigated as a monomer or cross-linker for creating polymers with unique mechanical properties.
• Chemical Biology: Utilized for bioconjugation and as a probe to study protein-ligand interactions.

Basic Information

Product Name	3-(Aminomethyl)Bicyclo[1.1.1]Pentane-1-Carbonitrile Hydrochloride
CAS No.	2231675-26-4
Molecular Formula	C8H11N2•HCl
Molecular Weight	186.65 g/mol
Synonyms	3-(Aminomethyl)bicyclo[1.1.1]pentane-1-carbonitrile hydrochloride; 1-Cyano-3-(aminomethyl)bicyclo[1.1.1]pentane hydrochloride; BCP-Nitrile-Amine HCl; [1.1.1]Propellane-1-carbonitrile, 3-(aminomethyl)-, hydrochloride; 3-(Aminomethyl)-1-cyanobicyclo[1.1.1]pentane hydrochloride; Aminomethyl-BCP-carbonitrile HCl; (3-(Aminomethyl)bicyclo[1.1.1]pentan-1-yl)carbonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Aminomethyl)Bicyclo[1.1.1]Pentane-1-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.