Description

2H-Pyrido[1,2-A]Pyrazine-7-Carboxamide, n-[(2,4-Difluorophenyl)Methyl]-1,8-Dihydro-2-[(1R)-3-Hydroxy-1-Methylpropyl]-9-Methoxy-1,8-Dioxo- is a sophisticated, high-purity pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. Pharmaceutical research and development organizations, as well as advanced fine chemical manufacturers, need this precise chemical building block to develop next-generation drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients, particularly in oncology and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Preclinical & Clinical Trial Material Manufacturing: Supplied under controlled conditions for the production of materials used in non-clinical and clinical studies.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of robust, scalable synthetic routes for pharmaceutical manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the global pharmaceutical pipeline.

Basic Information

Item	Details
Product Name	2H-Pyrido[1,2-A]Pyrazine-7-Carboxamide, n-[(2,4-Difluorophenyl)Methyl]-1,8-Dihydro-2-[(1R)-3-Hydroxy-1-Methylpropyl]-9-Methoxy-1,8-Dioxo-
CAS No.	2227442-13-7
Molecular Formula	C22H23F2N3O5
Molecular Weight	447.43 g/mol
Synonyms	N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-2-[(1R)-3-hydroxy-1-methylpropyl]-9-methoxy-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide; (R)-N-((2,4-Difluorobenzyl)-2-(3-hydroxy-1-methylpropyl)-9-methoxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide; 2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-2-[(1R)-3-hydroxy-1-methylpropyl]-9-methoxy-1,8-dioxo-; CAS 2227442-13-7; Difluorophenyl Pyridopyrazine Carboxamide Derivative; Advanced Pharmaceutical Intermediate 2227442-13-7
EINECS	Contact for details

Quality Control

Our 2H-Pyrido[1,2-A]Pyrazine-7-Carboxamide intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided, and we support compliance with relevant guidelines for advanced intermediates. Specifications can be aligned with client requirements for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.