Description

5-Ethynyl-3-Phenylpyrazin-2-Amine is a specialized pyrazine derivative featuring a reactive ethynyl group and an amine functionality. This compound serves as a versatile and high-value building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and agrochemical research teams for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation and proteomics research due to its click-chemistry compatible ethynyl group.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and exploratory synthesis projects.

Basic Information

Product Name	5-Ethynyl-3-Phenylpyrazin-2-Amine
CAS No.	2227272-78-6
Molecular Formula	C12H9N3
Molecular Weight	195.22 g/mol
Synonyms	3-Phenyl-5-ethynylpyrazin-2-amine; 2-Amino-5-ethynyl-3-phenylpyrazine; 5-Ethynyl-3-phenyl-2-pyrazinamine; 5-Ethynyl-3-phenylpyrazin-2-ylamine; 2227272-78-6; 5-Ethynyl-3-phenyl-pyrazin-2-amine
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-3-Phenylpyrazin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.