Description

8-Chloro-6-Iodoimidazo[1,2-A]Pyrazine is a high-value halogenated heterocyclic building block of significant interest in modern organic synthesis. This compound matters as a versatile precursor for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for lead optimization and the synthesis of targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Item	Details
Product Name	8-Chloro-6-Iodoimidazo[1,2-A]Pyrazine
CAS No.	2227272-49-1
Molecular Formula	C6H3ClIN3
Molecular Weight	279.46 g/mol
Synonyms	8-Chloro-6-iodoimidazo[1,2-a]pyrazine; Imidazo[1,2-a]pyrazine, 8-chloro-6-iodo-; 6-Iodo-8-chloroimidazo[1,2-a]pyrazine
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-Iodoimidazo[1,2-A]Pyrazine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports your R&D and scale-up activities with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.