Description

(4-Methylpiperazin-2-Yl)Methanol Dihydrochloride is a high-purity, pharmaceutically relevant building block and intermediate, supplied as a stable dihydrochloride salt. This compound is critical for medicinal chemistry research and development, offering a functionalized piperazine scaffold essential for constructing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting protein-protein interactions or kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the (4-methylpiperazin-2-yl)methanol pharmacophore.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Chemical Biology Probes: Utilized to create tool compounds and probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) specializing in custom, gram-to-kilogram scale synthesis for client projects.

Basic Information

Product Name	(4-Methylpiperazin-2-Yl)Methanol Dihydrochloride
CAS No.	2227206-74-6
Molecular Formula	C6H16Cl2N2O
Molecular Weight	203.11 g/mol
Synonyms	2-(Hydroxymethyl)-1-methylpiperazine Dihydrochloride; 1-Methyl-2-piperazinemethanol Dihydrochloride; (1-Methylpiperazin-2-yl)methanol Dihydrochloride; (4-Methyl-2-piperazinyl)methanol Dihydrochloride; (4-Methylpiperazin-2-yl)methanol Hydrochloride (1:2); 4-Methyl-2-piperazinylmethanol Dihydrochloride
EINECS	Contact for details

Quality Control

Our (4-Methylpiperazin-2-Yl)Methanol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.