Description

(1R,5S)-3-Benzyl-3-Azaspiro[Bicyclo[3.2.1]Octane-8,2'-[1,3]Dioxolane] Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and bridged bicyclic architecture. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique three-dimensional scaffold.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Employed in university and institutional labs for studying spirocyclic and nitrogen-containing heterocycle chemistry.
• Library Synthesis: Used to create diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	(1R,5S)-3-Benzyl-3-Azaspiro[Bicyclo[3.2.1]Octane-8,2'-[1,3]Dioxolane] Hydrochloride
CAS No.	2227206-10-0
Molecular Formula	C19H26ClNO2
Molecular Weight	335.87 g/mol
Synonyms	3-Benzyl-3-azaspiro[bicyclo[3.2.1]octane-8,2'-[1,3]dioxolane] hydrochloride; (1R,5S)-3-Benzyl-3-azaspiro[bicyclo[3.2.1]octane-8,2'-[1,3]dioxolane] HCl; 3-Benzyl-3-azaspiro[bicyclo[3.2.1]octane-8,2'-(1,3)dioxolane] hydrochloride; 2227206-10-0; 3-Azaspiro[bicyclo[3.2.1]octane-8,2'-[1,3]dioxolane], 3-benzyl-, hydrochloride, (1R,5S)-; Bicyclo[3.2.1]octane-8,2'-[1,3]dioxolane], 3-benzyl-3-aza-, hydrochloride, (1R,5S)-
EINECS	Contact for details

Quality Control

Our (1R,5S)-3-Benzyl-3-Azaspiro[Bicyclo[3.2.1]Octane-8,2'-[1,3]Dioxolane] Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.