Description

Amino-Peg24-Alcohol CAS NO 2226726-55-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a hydroxyl group at the other, separated by a 24-unit PEG spacer. This unique structure makes it an essential building block for creating stable, hydrophilic, and biocompatible linkers in advanced bioconjugation and nanotechnology applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors for developing targeted drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to drugs, surfaces, or other biomolecules while imparting solubility and reducing immunogenicity.
• PEGylation Reagent: Used in the site-specific modification of therapeutic proteins and peptides to enhance pharmacokinetic properties such as circulation half-life and stability.
• Diagnostic Probe Synthesis: Serves as a spacer arm in the construction of fluorescent, radioactive, or other labeled probes for imaging and detection assays.
• Nanoparticle Functionalization: Enables the surface modification of liposomes, dendrimers, and inorganic nanoparticles to improve biocompatibility and enable further chemical attachment.
• Hydrogel and Biomaterial Crosslinking: Acts as a versatile crosslinker or modifier in the synthesis of hydrogels and polymeric biomaterials for tissue engineering and controlled release.
• Surface Chemistry: Used to create amine- or hydroxyl-presenting self-assembled monolayers (SAMs) on gold, silicon, or other substrates for biosensor and chip development.
• Click Chemistry Intermediate: The amine and hydroxyl groups provide handles for further modification via a wide range of click chemistry and other coupling reactions.
• ADC (Antibody-Drug Conjugate) Development: A critical component in the linker-payload construct for next-generation ADCs, offering controlled release and stability profiles.

Basic Information

Product Name	Amino-Peg24-Alcohol
CAS No.	2226726-55-0
Molecular Formula	C50H103NO25 (Typical for PEG24 derivatives)
Molecular Weight	~1150.3 g/mol (Theoretical Average)
Synonyms	NH2-PEG24-OH; α-Amino-ω-hydroxy-tetraicosa(ethylene glycol); Amino-Polyethylene Glycol24-Alcohol; 2-Aminoethoxy-tetraicosa(oxyethylene)ethanol; Heterobifunctional PEG24 Amine Alcohol; Amine-PEG24-OH; PEG24 Diamine Monol; HO-PEG24-NH2
EINECS	Contact for details

Quality Control

Our Amino-Peg24-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Standard quality parameters include assay by NMR, purity determination by HPLC, and confirmation of amine content. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store the product under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. For long-term stability, it is recommended to store at -20°C or below. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Molecular Weight (NMR/SEC)	1100 - 1200 g/mol (Average)
Amine Value (Titration)	0.80 - 0.95 mmol/g
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.