Description

2-Bromo-5-(Oxetan-3-Yl)Pyrazine is a high-purity heterocyclic building block of significant interest in modern synthetic chemistry. This compound matters for its role as a versatile intermediate in the development of novel active pharmaceutical ingredients (APIs) and advanced materials. Pharmaceutical researchers and fine chemical manufacturers need it for constructing complex molecular architectures, particularly in medicinal chemistry programs targeting new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to the reactive bromine and the oxetane moiety, which can improve metabolic stability and solubility.
• Agrochemical Synthesis: Serves as a building block for creating novel active ingredients in crop protection products.
• Material Science Research: Employed in the synthesis of specialized ligands, functionalized polymers, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki, Negishi, or Buchwald-Hartwig amination.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems and target engagement.

Basic Information

Item	Details
Product Name	2-Bromo-5-(Oxetan-3-Yl)Pyrazine
CAS No.	2222934-73-6
Molecular Formula	C7H7BrN2O
Molecular Weight	215.05 g/mol
Synonyms	2-Bromo-5-(oxetan-3-yl)pyrazine; 5-(Oxetan-3-yl)-2-bromopyrazine; Pyrazine, 2-bromo-5-(oxetan-3-yl)-; 3-(5-Bromopyrazin-2-yl)oxetane; Oxetan-3-yl-pyrazine bromide derivative; BR-OPZ; Building block 2222934-73-6
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Oxetan-3-Yl)Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.