Description

Boc-Nh-Peg15-Nh2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyloxycarbonyl (Boc) protected amine at one terminus and a primary amine at the other. This compound is essential for creating stable, water-soluble, and biocompatible linkers in bioconjugation and drug delivery system development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for constructing peptide-PEG conjugates, antibody-drug conjugates (ADCs), and functionalized nanoparticles.

Application

• Bioconjugation Linker: Serves as a versatile spacer for coupling peptides, proteins, or antibodies to drugs, surfaces, or other biomolecules.
• ADC (Antibody-Drug Conjugate) Development: Used to create stable PEGylated linkers that connect cytotoxic payloads to targeting antibodies, improving solubility and pharmacokinetics.
• Peptide Synthesis & Modification: Enables the site-specific introduction of PEG chains into synthetic peptides to enhance stability and reduce immunogenicity.
• Nanoparticle Functionalization: Facilitates the surface modification of liposomes, dendrimers, and polymeric nanoparticles with amine groups for further coupling.
• Hydrogel & Biomaterial Cross-linking: Acts as a cross-linking agent or modifier in the synthesis of PEG-based hydrogels for tissue engineering and controlled release.
• Diagnostic Reagent Preparation: Employed in the design of contrast agents and fluorescent probes for imaging applications.

Basic Information

Product Name	Boc-Nh-Peg15-Nh2
CAS No.	2222566-55-2
Molecular Formula	C77H153N3O34
Molecular Weight	~1680.0 g/mol
Synonyms	Boc-NH-PEG15-NH2; Boc-Amine-PEG15-Amine; α-Boc-amino-ω-amino-pentaethylene glycol; 2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{3-[(2-Methyl-2-propanyl)oxycarbonylamino]propoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethanamine; tert-Butyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate; Heterobifunctional PEG 15, Boc-NH2; Boc-protected PEG diamine (n=15)
EINECS	Contact for details

Quality Control

Our Boc-Nh-Peg15-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC/SEC)	Confirmed
Functional Group Assay (NMR/Titration)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.