Description

1-Piperazinecarboxylic Acid, 4-[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-5-Yl]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in targeted therapeutic areas, offering a reliable building block for medicinal chemistry. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex APIs, particularly for targeted cancer therapies and immunomodulators.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a critical linker or warhead component in the design of novel heterobifunctional degraders.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Preclinical & Clinical Research: Supplied in GMP or high-purity grades to support regulatory filings and scale-up activities.
• Chemical Biology Research: Employed as a tool compound to study protein-protein interactions and cellular degradation pathways.
• Custom Synthesis: Basis for the custom manufacturing of specialized derivatives and analogs for proprietary research programs.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 4-[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-5-Yl]-, 1,1-Dimethylethyl Ester
CAS No.	2222114-64-7
Molecular Formula	C22H26N4O6
Molecular Weight	442.47 g/mol
Synonyms	tert-Butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate; 5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Lenalidomide-Piperazine-Boc Intermediate; PROTAC Linker Intermediate; E3 Ligase Ligand Derivative; Cereblon Ligand Building Block; (3-(5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione)
EINECS	Contact for details

Quality Control

Our production of 1-Piperazinecarboxylic Acid, 4-[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-5-Yl]-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each batch, detailing all critical specifications. We support development from non-GMP research to cGMP-grade material for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.