Description

2-(2,6-Dioxopiperidin-3-Yl)-5-Fluoro-6-(Piperazin-1-Yl)Isoindoline-1,3-Dione Hcl is a high-purity pharmaceutical intermediate and research chemical of significant interest in modern drug discovery. This compound is valued for its role as a key building block in the synthesis of novel targeted protein degraders, such as Proteolysis Targeting Chimeras (PROTACs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in developing next-generation therapeutics for oncology and other challenging disease areas.

Application

• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a critical cereblon-binding ligand (or "warhead") for constructing bifunctional molecules designed to degrade specific disease-causing proteins.
• Pharmaceutical Research & Synthesis: Acts as a versatile intermediate in the synthesis of novel small molecule drugs targeting E3 ubiquitin ligase pathways.
• Oncology Drug Discovery: Used in preclinical research for developing targeted cancer therapies that leverage the ubiquitin-proteasome system.
• Chemical Biology Studies: Employed as a tool compound to study protein-protein interactions, degradation mechanisms, and cellular signaling pathways.
• Academic & Institutional Research: Supports fundamental research in medicinal chemistry, biochemistry, and molecular pharmacology.
• Process Development & Scale-up: Used in optimizing synthetic routes and manufacturing processes for advanced therapeutic candidates.

Basic Information

Product Name	2-(2,6-Dioxopiperidin-3-Yl)-5-Fluoro-6-(Piperazin-1-Yl)Isoindoline-1,3-Dione Hydrochloride
CAS No.	2222114-23-8
Molecular Formula	C17H17FN4O4 • HCl
Molecular Weight	407.80 g/mol (Free base: 372.35 g/mol)
Synonyms	5-Fluoro-6-(piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride; 5-Fluoro-6-(1-piperazinyl)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride; Thalidomide derivative, fluorinated; Cereblon ligand derivative HCl salt; PROTAC intermediate HCl salt; IMiD (Immunomodulatory imide drug) analog.
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dioxopiperidin-3-Yl)-5-Fluoro-6-(Piperazin-1-Yl)Isoindoline-1,3-Dione Hcl is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and mass spectrometry. We support our clients with the documentation required for their regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be handled accordingly to maintain stability. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.