Description

1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-5-Fluoro-6-(1-Piperazinyl)- is a high-purity, fluorinated heterocyclic compound featuring a complex molecular architecture that combines isoindole-1,3-dione, piperidine-2,6-dione, and piperazine motifs. This structure makes it a critical advanced intermediate for the synthesis of novel pharmaceutical agents, particularly in oncology and targeted therapies. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing next-generation small molecule drugs and proteolysis-targeting chimeras (PROTACs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• PROTAC Linker & Warhead Component: Utilized in the design and construction of Proteolysis-Targeting Chimeras due to its piperazine and dioxopiperidine groups, which can act as connectors or functional elements.
• Kinase Inhibitor Development: Acts as a core scaffold or precursor for developing potent and selective kinase inhibitors, leveraging the fluorine atom for improved metabolic stability and binding affinity.
• Chemical Biology Research: Employed as a molecular probe or tool compound to study protein-protein interactions and intracellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific candidate drugs under cGMP conditions.
• Academic Research: Used in university and institutional laboratories for medicinal chemistry programs and drug discovery projects.

Basic Information

Product Name	1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-5-Fluoro-6-(1-Piperazinyl)-
CAS No.	2222114-22-7
Molecular Formula	C17H17FN4O4
Molecular Weight	360.34 g/mol
Synonyms	5-Fluoro-6-(piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-Dioxo-3-piperidyl)-5-fluoro-6-(1-piperazinyl)-1H-isoindole-1,3(2H)-dione; 5-Fluoro-6-piperazinyl-2-(2,6-dioxo-3-piperidinyl)phthalimide; Fluorinated Dioxopiperidinyl Phthalimide Piperazine Derivative; PROTAC Intermediate 2222114-22-7; (3-(5-Fluoro-6-(piperazin-1-yl)-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and LC-MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development with custom synthesis and can align our quality controls with specific client protocols or emerging regulatory guidelines for novel pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.