Description

6-Chloro-3-Iodo-1-Tetrahydropyran-2-Yl-Pyrazolo[3,4-B]Pyrazine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for pharmaceutical research and development, serving as a key intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) and other complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated pyrazolo-pyrazine motifs into their target structures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require halogenated heterocyclic cores.
• Material Science Precursor: Serves as a specialized monomer or ligand precursor for creating advanced organic electronic materials or metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Academic Research: Used in university and institutional labs for methodological development in cross-coupling reactions and heterocyclic chemistry.

Basic Information

Product Name	6-Chloro-3-Iodo-1-Tetrahydropyran-2-Yl-Pyrazolo[3,4-B]Pyrazine
CAS No.	2215028-64-9
Molecular Formula	C10H8ClIN4O
Molecular Weight	362.55 g/mol
Synonyms	6-Chloro-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyrazine; 1-(Tetrahydro-2H-pyran-2-yl)-6-chloro-3-iodo-1H-pyrazolo[3,4-b]pyrazine; THP-protected 6-chloro-3-iodopyrazolo[3,4-b]pyrazine; 6-Chloro-3-iodo-1-(THP)-pyrazolo[3,4-b]pyrazine; Pyrazolo[3,4-b]pyrazine, 6-chloro-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-; 2215028-64-9; 6-Cl-3-I-1-THP-Pyrazolo[3,4-b]pyrazine
EINECS	Contact for details

Quality Control

Our 6-Chloro-3-Iodo-1-Tetrahydropyran-2-Yl-Pyrazolo[3,4-B]Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability, consistency, and reliability for your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.