Description

2-Piperazinemethanol, 5-Methyl-, (2R,5S)- CAS NO 2206741-25-3 is a chiral piperazine derivative, a high-value building block of significant interest in advanced organic synthesis. Its defined stereochemistry and functionalized structure make it a critical intermediate for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereospecificity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Catalyst Ligand Precursor: Used in the synthesis of sophisticated ligands for metal-catalyzed asymmetric reactions, enabling the production of enantiomerically pure compounds.
• Agrochemical Synthesis: Serves as a building block for creating advanced, stereospecific agrochemicals and plant growth regulators.
• Peptidomimetic Chemistry: Incorporated into the design of peptidomimetics and other bioactive molecules that mimic peptide structures for enhanced stability and efficacy.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, stereochemically defined intermediates.
• Academic & Industrial Research: Utilized in chemical research laboratories for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	2-Piperazinemethanol, 5-Methyl-, (2R,5S)-
CAS No.	2206741-25-3
Molecular Formula	C6H14N2O
Molecular Weight	130.19 g/mol
Synonyms	(2R,5S)-5-Methyl-2-piperazinemethanol; (2R,5S)-5-Methylpiperazine-2-methanol; (2R,5S)-2-(Hydroxymethyl)-5-methylpiperazine; (2R,5S)-1,4-Diazacyclohexane-2-methanol, 5-methyl-; (2R,5S)-5-Methyl-1,4-diazacyclohexane-2-methanol; (2R,5S)-5-Methyl-2-piperazinylmethanol; (2R,5S)-5-Methyl-2-piperazinmethanol; (2R,5S)-5-Methyl-2-piperazin-1-ylmethanol
EINECS	Contact for details

Quality Control

Our 2-Piperazinemethanol, 5-Methyl-, (2R,5S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2R,5S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.