Description

Hexahydro-2H-Pyrazino[1,2-A]Pyrazin-1(6H)-One Dihydrochloride is a high-purity, specialized organic compound primarily used as a key building block in pharmaceutical research and development. This compound is critical for medicinal chemists working on novel drug candidates, particularly in the areas of central nervous system (CNS) and metabolic disease therapies. Its unique fused bicyclic piperazine-pyrazinone structure makes it a valuable intermediate for synthesizing complex molecules with potential therapeutic activity. Pharmaceutical R&D laboratories and fine chemical manufacturers are the primary industrial users seeking this advanced chemical intermediate.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for drug discovery programs.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS).
• Process Chemistry Development: Acts as a starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material.
• Chemical Biology Probes: Utilized in the development of tool compounds to study biological pathways and target validation.
• Academic Research: Used in university and institutional labs for fundamental organic synthesis and pharmacology studies.

Basic Information

Product Name	Hexahydro-2H-Pyrazino[1,2-A]Pyrazin-1(6H)-One Dihydrochloride
CAS No.	2197416-30-9
Molecular Formula	C8H16Cl2N4O
Molecular Weight	255.15 g/mol
Synonyms	1,4-Diazabicyclo[4.3.0]nonan-9-one dihydrochloride; 2H-Pyrazino[1,2-a]pyrazin-1(6H)-one, hexahydro-, dihydrochloride; Hexahydropyrazino[1,2-a]pyrazin-1(6H)-one dihydrochloride; Fused Bicyclic Piperazine Dihydrochloride Salt; (1R,6S)-Hexahydro-2H-pyrazino[1,2-a]pyrazin-1(6H)-one dihydrochloride (for specific stereoisomer); 2197416-30-9; CAS 2197416-30-9
EINECS	Contact for details

Quality Control

Our Hexahydro-2H-Pyrazino[1,2-A]Pyrazin-1(6H)-One Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We can support development with custom purity grades, including >95%, >98%, and >99% (HPLC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.