Description

trans-1-Cbz-4-Amino-3-Methoxypiperidine Hydrochloride is a high-purity, protected piperidine derivative used as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the construction of complex pharmacophores and active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel therapeutic agents, including potential central nervous system (CNS) drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetic Synthesis: Used in the design and synthesis of peptide analogs and mimetics to enhance metabolic stability and bioavailability.
• Chemical Biology Probe Development: Employed in the creation of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	trans-1-Cbz-4-Amino-3-Methoxypiperidine Hydrochloride
CAS No.	2177264-15-0
Molecular Formula	C14H21N2O3 • HCl
Molecular Weight	308.79 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-amino-3-methoxypiperidine hydrochloride (trans); (3R,4R)-1-[(Benzyloxy)carbonyl]-4-amino-3-methoxypiperidine hydrochloride; (3S,4S)-1-[(Benzyloxy)carbonyl]-4-amino-3-methoxypiperidine hydrochloride; trans-1-Cbz-4-Amino-3-Methoxy-piperidine HCl; trans-4-Amino-3-methoxy-1-N-Cbz-piperidine hydrochloride; 1-N-Cbz-4-Amino-3-methoxypiperidine hydrochloride (trans); Benzyl (3R,4R)-4-amino-3-methoxypiperidine-1-carboxylate hydrochloride; Benzyl (3S,4S)-4-amino-3-methoxypiperidine-1-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our trans-1-Cbz-4-Amino-3-Methoxypiperidine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D, and we can support custom synthesis projects with specific analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.