Description

1-Piperidineethanol, 3-[1-[1-[(1R)-1-(2,4-Dichlorophenyl)Ethyl]-3-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyrazin-6-Yl]-3-Azetidinyl]-, (3R)- is a high-purity, chiral advanced pharmaceutical intermediate (API) characterized by its complex heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily sought after by pharmaceutical R&D organizations and contract manufacturing organizations (CMOs) engaged in the development of small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for investigational drugs.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of compound libraries targeting specific biological pathways.
• Preclinical Research: Essential for producing batches of candidate compounds for pharmacological profiling, toxicology studies, and formulation development.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing scales.
• Targeted Therapy Development: Its specific structural motifs suggest potential application in developing therapies for oncology, inflammatory diseases, or central nervous system (CNS) disorders.

Basic Information

Product Name	1-Piperidineethanol, 3-[1-[1-[(1R)-1-(2,4-Dichlorophenyl)Ethyl]-3-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyrazin-6-Yl]-3-Azetidinyl]-, (3R)-
CAS No.	2174938-78-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3R)-3-[1-[1-[(1R)-1-(2,4-Dichlorophenyl)ethyl]-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3-azetidinyl]-1-piperidineethanol; UNII-8I4H6W6G4F; 8I4H6W6G4F; 1-Piperidineethanol, 3-[1-[1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3-azetidinyl]-, (3R)-; (3R)-3-(1-{(1R)-1-(2,4-Dichlorophenyl)ethyl]-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl}azetidin-3-yl)-1-piperidineethanol
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, chiral HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) with full traceability are provided for each lot. Our quality commitment aligns with the standards expected for cGMP starting materials and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.