Description

(7S,8Ar)-Octahydropyrrolo[1,2-A]Piperazin-7-Ol Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its complex, fused bicyclic piperazine structure. This compound matters as a critical chiral building block for the synthesis of novel, biologically active molecules, particularly in central nervous system (CNS) and other therapeutic areas. Pharmaceutical R&D and process chemistry teams need it for developing new active pharmaceutical ingredients (APIs) and for scaling up production under controlled GMP conditions.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for neurological and psychiatric disorders.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a rigid, nitrogen-containing bicyclic scaffold.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Development & Scale-up: Employed in route scouting, optimization, and kilogram-to-ton scale manufacturing for clinical trial material and commercial API supply.
• Asymmetric Synthesis: Utilized in stereoselective reactions due to its defined (7S,8Ar) stereochemistry, enabling the creation of enantiomerically pure final products.
• Preclinical & Clinical Development: Supplies material for formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) profiling, and toxicology assessments.

Basic Information

Product Name	(7S,8Ar)-Octahydropyrrolo[1,2-A]Piperazin-7-Ol Dihydrochloride
CAS No.	2173637-06-2
Molecular Formula	C8H17Cl2N3O
Molecular Weight	242.15 g/mol
Synonyms	(7S,8Ar)-Octahydro-1H-pyrrolo[1,2-a]piperazin-7-ol dihydrochloride; (7S,8aR)-Octahydropyrrolo[1,2-a]pyrazin-7-ol dihydrochloride; 1H-Pyrrolo[1,2-a]piperazin-7-ol, octahydro-, (7S,8aR)-, dihydrochloride; Bicyclic Piperazine Dihydrochloride Salt; CAS 2173637-06-2
EINECS	Contact for details

Quality Control

Our (7S,8Ar)-Octahydropyrrolo[1,2-A]Piperazin-7-Ol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.