Description

Mpeg12-Ch2Ch2Cooh is a specialized methoxy polyethylene glycol (mPEG) carboxylic acid derivative, designed for precision conjugation and surface modification. This compound is engineered to provide a reactive carboxyl terminus for covalent attachment to biomolecules, nanoparticles, and other substrates, enabling controlled functionalization and enhanced solubility. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require reliable, high-purity linkers for drug delivery systems, diagnostic assays, and polymer synthesis.

Application

• Bioconjugation & Drug Delivery: Acts as a key linker for attaching therapeutic agents (e.g., peptides, proteins, small molecules) to PEG chains, creating PEGylated prodrugs with improved pharmacokinetics and reduced immunogenicity.
• Surface Functionalization: Used to modify the surface of nanoparticles, quantum dots, and medical devices with carboxyl groups, facilitating subsequent coupling with amines for targeted applications.
• Polymer Synthesis: Serves as a macroinitiator or monomer in the synthesis of block copolymers and functionalized hydrogels for controlled release and tissue engineering.
• Diagnostic Reagents: Employed in the development of immunoassays and biosensors by conjugating detection molecules (e.g., antibodies, enzymes) to enhance stability and performance in aqueous media.
• Chromatography & Separation Media: Functionalizes stationary phases for affinity chromatography and other separation techniques to improve selectivity for biomolecules.

Basic Information

Product Name	Mpeg12-Ch2Ch2Cooh
CAS No.	2170098-33-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	mPEG12-acetic acid; Methoxy-PEG12-acid; α-Methoxy-ω-carboxypentadecaethylene glycol; mPEG(12)-COOH; Poly(ethylene glycol) methyl ether carboxylic acid (n~12); 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; PEG-based carboxylic acid linker
EINECS	Contact for details

Quality Control

Our Mpeg12-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and end-group analysis to ensure consistency and performance. A detailed Certificate of Analysis (COA) documenting identity, purity, and relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and prevent hydrolysis of the active carboxyl group.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	To be specified per batch
Molecular Weight Distribution (GPC)	To be specified per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.