Description

Mpeg16-Propyne CAS NO 2169967-47-7 is a functionalized polyethylene glycol (PEG) derivative featuring a terminal alkyne group, designed for advanced bioconjugation and materials science applications. This compound is critical for researchers and manufacturers requiring precise, site-specific modification of biomolecules and surfaces via click chemistry reactions. It is primarily utilized in the development of targeted drug delivery systems, diagnostic agents, and functional hydrogels within the pharmaceutical and biotechnology sectors.

Application

• Bioconjugation Linker: Enables site-specific attachment of drugs, peptides, or fluorescent probes to antibodies, proteins, and nanoparticles via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Drug Delivery Systems: Serves as a key building block for creating PEGylated prodrugs and targeted nanocarriers to enhance solubility, prolong circulation time, and reduce immunogenicity.
• Diagnostic Probe Synthesis: Used to conjugate imaging agents (e.g., fluorophores, radiolabels) to targeting molecules for in vitro and in vivo diagnostics.
• Surface Functionalization: Modifies material surfaces (e.g., gold nanoparticles, glass, polymers) to introduce bio-active sites for sensor development and tissue engineering scaffolds.
• Hydrogel Cross-linking: Acts as a cross-linker in the synthesis of smart, biodegradable hydrogels for controlled release and 3D cell culture applications.
• Polymer Chemistry: Functions as a macromonomer or initiator in the synthesis of block copolymers with tailored functionality for advanced material design.

Basic Information

Product Name	Mpeg16-Propyne
CAS No.	2169967-47-7
Molecular Formula	Contact for details
Molecular Weight	~ 800 g/mol (for n=16)
Synonyms	mPEG16-Alkyne; Methoxy PEG16 Propyne; α-Methoxy-ω-propynyl-poly(ethylene glycol); Poly(ethylene glycol) methyl ether propargyl ether (n~16); Propargyl-PEG16-OMe; Alkyne-PEG16-OCH3; Click Chemistry PEG Reagent
EINECS	Contact for details

Quality Control

Our Mpeg16-Propyne is manufactured under GMP-like conditions to ensure batch-to-batch consistency for research and pre-clinical applications. Each lot undergoes rigorous analytical testing, including NMR and HPLC for structural confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing purity, functional group substitution, and critical impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), desiccate at -20°C.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Average Molecular Weight (Mn)	~ 800 Da
Polydispersity Index (PDI)	≤ 1.05
Alkyne Substitution	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.