Description

Benzyl (3-Formylbicyclo[1.1.1]pentan-1-yl)carbamate is a specialized, high-purity chemical building block featuring a unique bicyclo[1.1.1]pentane (BCP) scaffold. This compound is engineered to provide medicinal chemists with a novel, three-dimensional structural motif to enhance the physicochemical properties of drug candidates, such as improving metabolic stability and membrane permeability. It is primarily utilized in pharmaceutical R&D for the synthesis of innovative small-molecule therapeutics, agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for creating novel bioisosteres.
• Medicinal Chemistry Research: Used to incorporate the rigid, three-dimensional bicyclo[1.1.1]pentane core into lead compounds to optimize potency, selectivity, and ADMET profiles.
• Agrochemical Synthesis: Serves as a building block for developing new generation crop protection agents with potentially improved efficacy and environmental safety.
• Advanced Material Precursor: Employed in the synthesis of specialty polymers and functional materials that require unique steric and electronic properties.
• Chemical Biology Probes: Useful for creating molecular tools and probes to study biological systems and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-value, complex intermediates.

Basic Information

Product Name	Benzyl (3-Formylbicyclo[1.1.1]pentan-1-yl)carbamate
CAS No.	2166952-44-7
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	Carbamic acid, N-(3-formylbicyclo[1.1.1]pent-1-yl)-, phenylmethyl ester; BnOCO-NH-BCP-CHO; Benzyl N-(3-formylbicyclo[1.1.1]pentan-1-yl)carbamate; 1-((Benzyloxy)carbonylamino)-3-formylbicyclo[1.1.1]pentane; 3-Formylbicyclo[1.1.1]pentane-1-carboxylic acid benzylamide (related); BCP-CHO-NHCbz; Bicyclo[1.1.1]pentane-1-carboxaldehyde, 1-(((benzyloxy)carbonyl)amino)-
EINECS	Contact for details

Quality Control

Our Benzyl (3-Formylbicyclo[1.1.1]pentan-1-yl)carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.