Description

(3S)-4-Boc-3-Acetylmorpholine is a high-purity, chiral building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production teams in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemistry and reliable quality for their synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetics Research: Used in the design and construction of peptidomimetic compounds, where the morpholine scaffold mimics peptide bonds to enhance metabolic stability.
• Asymmetric Synthesis: Serves as a versatile building block in asymmetric catalytic reactions and multi-step syntheses requiring high enantiomeric purity.
• Agrochemical Development: Employed in the research phase for creating new, more effective pesticides and herbicides with specific chiral activity.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands and organocatalysts used in fine chemical and pharmaceutical manufacturing.
• Chemical Biology Probes: Incorporated into molecular probes for studying biological pathways and enzyme functions in academic and industrial R&D.

Basic Information

Product Name	(3S)-4-Boc-3-Acetylmorpholine
CAS No.	2166202-37-3
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(3S)-4-(tert-Butoxycarbonyl)-3-acetylmorpholine; (3S)-3-Acetyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine; (S)-4-Boc-3-acetylmorpholine; tert-Butyl (3S)-3-acetylmorpholine-4-carboxylate; Boc-3-Acetylmorpholine (S-enantiomer); (S)-3-Acetyl-4-(Boc)morpholine; 4-Boc-3-acetylmorpholine, (3S)-
EINECS	Contact for details

Quality Control

Our (3S)-4-Boc-3-Acetylmorpholine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.