Description

(R)-1-(tert-Butoxycarbonyl)-5,5-Difluoropiperidine-3-Carboxylic Acid is a high-purity, chiral piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Peptidomimetic Chemistry: Used to introduce constrained, fluorinated piperidine motifs into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor for developing novel, fluorinated active ingredients with potential insecticidal or herbicidal properties.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Utilized to create fluorinated molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Process Chemistry: Acts as a standardized starting material for scaling up the production of target molecules under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	(R)-1-(tert-Butoxycarbonyl)-5,5-Difluoropiperidine-3-Carboxylic Acid
CAS No.	2166031-07-6
Molecular Formula	C11H17F2NO4
Molecular Weight	265.26 g/mol
Synonyms	(R)-1-Boc-5,5-difluoropiperidine-3-carboxylic acid; tert-Butyl (3R)-5,5-difluoro-3-(carboxymethyl)piperidine-1-carboxylate; (3R)-1-(tert-Butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid; Boc-5,5-Difluoro-D-pipecolic acid; (R)-5,5-Difluoro-1-N-Boc-piperidine-3-carboxylic acid; 1-Boc-5,5-difluoro-(R)-piperidine-3-carboxylic acid; CAS 2166031-07-6
EINECS	Contact for details

Quality Control

Our (R)-1-(tert-Butoxycarbonyl)-5,5-Difluoropiperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral excess (typically ≥99% ee), and impurity profiles is provided with every shipment. We support development with custom purity grades and analytical method data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.