Description

(2S,6R)-4-(tert-Butoxycarbonyl)-6-Methylmorpholine-2-Carboxylic Acid CAS NO 2166009-21-6 is a high-purity, stereochemically defined morpholine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a protected, functionalized scaffold for constructing complex molecules with precise stereochemical control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially for central nervous system (CNS) and antiviral therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained morpholine motifs that mimic peptide backbones, enhancing metabolic stability and bioavailability in drug design.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Employed in the research and development of advanced, stereospecific pesticides and herbicides.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and the exploration of new synthetic pathways.
• Custom Synthesis and Contract Manufacturing: A specified starting material or intermediate for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(2S,6R)-4-(tert-Butoxycarbonyl)-6-Methylmorpholine-2-Carboxylic Acid
CAS No.	2166009-21-6
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	(2S,6R)-6-Methyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid; Boc-6-Methylmorpholine-2-carboxylic Acid (2S,6R-isomer); tert-Butyl (2S,6R)-2-carboxy-6-methylmorpholine-4-carboxylate; (2S,6R)-Boc-6-Methylmorpholine-2-COOH; (2S,6R)-4-Boc-6-methylmorpholine-2-carboxylic acid; Boc-(2S,6R)-6-methylmorpholine-2-carboxylic acid; 2166009-21-6
EINECS	Contact for details

Quality Control

Our (2S,6R)-4-(tert-Butoxycarbonyl)-6-Methylmorpholine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity (>99% ee/de) and chemical purity (typically >97%). Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee (2S,6R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.