Description

(S)-Benzyl 2-(Cyanomethyl)Piperazine-1-Carboxylate Hydrochloride is a high-purity chiral piperazine derivative, serving as a critical synthetic intermediate in modern pharmaceutical research and development. Its value lies in its role as a key building block for constructing complex molecules with specific stereochemistry, enabling the creation of targeted active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on novel therapeutics.

Application

• Pharmaceutical Intermediate: A crucial chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• API Synthesis: Used in the development and scale-up of Active Pharmaceutical Ingredients (APIs) requiring a specific (S)-configured piperazine scaffold.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery pipelines.
• Process Chemistry: Serves as a starting material or advanced intermediate in the optimization of commercial-scale synthetic routes for GMP manufacturing.
• Custom Synthesis: A valuable substrate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	(S)-Benzyl 2-(Cyanomethyl)Piperazine-1-Carboxylate Hydrochloride
CAS No.	2158302-02-2
Molecular Formula	C14H18N3O2 • HCl
Molecular Weight	297.77 g/mol (Free base: 261.31 g/mol)
Synonyms	(S)-Benzyl 2-(cyanomethyl)piperazine-1-carboxylate HCl; (S)-1-(Benzyloxycarbonyl)-2-(cyanomethyl)piperazine hydrochloride; (S)-Cbz-2-(Cyanomethyl)piperazine hydrochloride; (S)-1-CBZ-2-(Cyanomethyl)piperazine HCl; (S)-2-(Cyanomethyl)-1-[(phenylmethoxy)carbonyl]piperazine hydrochloride; (S)-N-Carbobenzoxy-2-(cyanomethyl)piperazine hydrochloride; (S)-1-N-CBZ-2-(Cyanomethyl)piperazine hydrochloride; (S)-Piperazine-1-carboxylic acid benzyl ester 2-(cyanomethyl) hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Benzyl 2-(Cyanomethyl)Piperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical development, supporting regulatory filings from preclinical through to commercial stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and opened under a dry atmosphere to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.