Description

1-Benzyl 4-(tert-Butyl) (S)-2-(Cyanomethyl)Piperazine-1,4-Dicarboxylate is a high-purity, single-enantiomer piperazine derivative serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in providing a protected, stereochemically defined scaffold for the efficient synthesis of complex bioactive molecules, particularly in medicinal chemistry. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors who are developing novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological and viral diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with improved efficacy and pharmacokinetic profiles.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of novel protease inhibitors due to its piperazine backbone and protected functional groups.
• Peptidomimetic Synthesis: Employed to construct peptidomimetic compounds that mimic natural peptides but with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in asymmetric catalytic reactions to introduce stereogenic centers with high enantiomeric purity.
• Contract Research & Manufacturing (CRMO): Supplied to CRMO organizations for custom synthesis projects and the production of non-commercial drug candidates for clinical trials.

Basic Information

Product Name	1-Benzyl 4-(tert-Butyl) (S)-2-(Cyanomethyl)Piperazine-1,4-Dicarboxylate
CAS No.	2158302-00-0
Molecular Formula	C19H25N3O4
Molecular Weight	359.42 g/mol
Synonyms	(S)-1-Benzyl 4-tert-butyl 2-(cyanomethyl)piperazine-1,4-dicarboxylate; (S)-1-(Benzyloxycarbonyl)-4-(tert-butoxycarbonyl)-2-(cyanomethyl)piperazine; (S)-Cbz-N-Boc-2-(Cyanomethyl)piperazine; (S)-1-N-Cbz-4-N-Boc-2-(Cyanomethyl)piperazine; (S)-2-(Cyanomethyl)-1,4-bis(oxycarbonyl)piperazine (benzyl and tert-butyl esters); (S)-N-Cbz-N'-Boc-2-(Cyanomethyl)piperazine; (S)-1,4-Di-Boc/Cbz-2-(Cyanomethyl)piperazine (mixed protecting groups); (S)-Piperazine-1,4-dicarboxylic acid, 2-(cyanomethyl)-, 1-(phenylmethyl) 4-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1-Benzyl 4-(tert-Butyl) (S)-2-(Cyanomethyl)Piperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays, ensuring compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.