Description

Abt-263-Piperazine CAS NO 2143096-93-7 is a high-purity, advanced pharmaceutical intermediate and building block. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and fine chemical manufacturers engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in the discovery and optimization of lead compounds for various therapeutic targets, including oncology.
• Bioconjugation & Probe Development: Serves as a linker or functional group in the development of biochemical probes and targeted drug conjugates.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating specialized, high-value chemical entities.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for fundamental and applied chemical research.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for organizations providing custom synthesis and process development services.

Basic Information

Product Name	Abt-263-Piperazine
CAS No.	2143096-93-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ABT-263 Piperazine derivative; Navitoclax Piperazine intermediate; BCL-2 inhibitor intermediate; 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(2R)-4-morpholin-2-ylphenyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide related piperazine; Piperazine, ABT-263 related substance
EINECS	Contact for details

Quality Control

Our Abt-263-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The material may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.