Description

Azd5991 CAS NO 2143010-83-5 is a potent and selective small molecule inhibitor of MCL-1 (Myeloid Cell Leukemia 1), a key anti-apoptotic protein. This compound is of significant interest for its potential to overcome resistance in various cancers by directly targeting the apoptotic pathway. It is primarily utilized by pharmaceutical researchers and development teams in the fields of oncology and hematology for preclinical studies and as a critical tool compound.

Application

• Oncology Research: As a research-grade chemical for investigating the role of MCL-1 in cancer cell survival and resistance mechanisms.
• Drug Discovery & Development: Serving as a lead compound or reference standard in the development of novel MCL-1 targeted cancer therapies.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro studies to evaluate MCL-1 inhibition and downstream apoptotic effects.
• Hematological Malignancy Studies: Applied in research focused on acute myeloid leukemia (AML), multiple myeloma, and lymphomas where MCL-1 is a validated target.
• Combination Therapy Research: Investigated in conjunction with other chemotherapeutic agents or BCL-2 family inhibitors to enhance therapeutic efficacy.
• Apoptosis Pathway Analysis: A key tool for studying the intrinsic (mitochondrial) apoptosis pathway in cellular and molecular biology.

Basic Information

Product Name	Azd5991
CAS No.	2143010-83-5
Molecular Formula	C30H31N5O5S
Molecular Weight	573.66 g/mol
Synonyms	Azd-5991; AZD-5991; AZD 5991; MCL-1 Inhibitor AZD5991; (S)-N-((S)-1-(4-(4-(((R)-4-Ethyl-2,5-dioxoimidazolidin-1-yl)methyl)phenyl)piperazin-1-yl)-3-(4-(4-methylthiazol-5-yl)phenyl)-1-oxopropan-2-yl)-2-methylpropane-2-sulfinamide; 2-Methylpropane-2-sulfinamide, N-[(1S)-1-[4-[4-[[(4R)-4-ethyl-2,5-dioxo-1-imidazolidinyl]methyl]phenyl]-1-piperazinyl]-3-[4-(4-methyl-5-thiazolyl)phenyl]-1-oxo-2-propanyl]-, (1S)-
EINECS	Contact for details

Quality Control

Our Azd5991 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.