Description

Methyl (3R,4R)-4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hcl is a high-purity chiral building block of significant importance in modern pharmaceutical research and development. Its value lies in its defined stereochemistry and the presence of the trifluoromethyl group, which is a key pharmacophore known to enhance metabolic stability and membrane permeability in drug candidates. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, particularly in the areas of central nervous system (CNS) disorders, oncology, and antiviral applications.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting protease inhibitors and other enzyme modulators.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR), leveraging the trifluoromethyl group's beneficial properties.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the development of robust, scalable synthetic routes for candidate drugs.
• Preclinical Drug Development: Employed in the preparation of compounds for pharmacological profiling, pharmacokinetic studies, and toxicology assessments.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical and biotechnology industries with custom synthesis projects.

Basic Information

Product Name	Methyl (3R,4R)-4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hcl
CAS No.	2140264-93-1
Molecular Formula	C8H11F3NO2 • HCl
Molecular Weight	249.63 g/mol (Free base: 210.17)
Synonyms	(3R,4R)-Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate hydrochloride; Methyl (3R,4R)-4-(trifluoromethyl)-3-pyrrolidinecarboxylate hydrochloride; (3R,4R)-4-(Trifluoromethyl)pyrrolidine-3-carboxylic acid methyl ester hydrochloride; (3R,4R)-1-Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate HCl; (3R,4R)-4-Trifluoromethyl-pyrrolidine-3-carboxylic acid methyl ester HCl salt; CAS 2140264-93-1
EINECS	Contact for details

Quality Control

Our Methyl (3R,4R)-4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing specifications such as chiral purity, chemical purity (HPLC), and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.