Description

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-(4-(4-Methylthiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide Dihydrochloride is a high-purity, non-natural amino acid derivative and a key pharmaceutical intermediate. This compound is critical for research and development in targeted drug discovery programs, particularly in the synthesis of complex therapeutic molecules. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly protease inhibitors.
• Peptidomimetic Research: Used in medicinal chemistry for designing and synthesizing peptide analogs with enhanced stability and bioavailability.
• Bioconjugation: Serves as a specialized linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Employed in the creation of activity-based probes for studying enzyme function and mechanism.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-(4-(4-Methylthiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide Dihydrochloride
CAS No.	2137142-47-1
Molecular Formula	C24H35Cl2N5O3S
Molecular Weight	544.54 g/mol
Synonyms	1-[(2S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-L-prolinamide dihydrochloride; (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((4-(4-methylthiazol-5-yl)phenyl)methyl)pyrrolidine-2-carboxamide dihydrochloride; UNII-9Y1V7J7Q8F; 9Y1V7J7Q8F; TFA Salt of Boceprevir Intermediate; Boceprevir Related Compound; Protease Inhibitor Intermediate; Advanced Pharmaceutical Intermediate
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-(4-(4-Methylthiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.