Description

(R)-tert-Butyl 2-Benzyl-4-Methylpiperazine-1-Carboxylate Hydrochloride is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold essential for developing active pharmaceutical ingredients (APIs) with specific biological activity. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates.
• API Development: Serves as a core structural component for potential APIs targeting neurological receptors.
• Asymmetric Synthesis: Utilized in reactions requiring a stereocontrolled piperazine moiety to induce desired chirality in final molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Employed in developing and optimizing robust, scalable synthetic routes for clinical trial material production.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	(R)-tert-Butyl 2-Benzyl-4-Methylpiperazine-1-Carboxylate Hydrochloride
CAS No.	2135344-94-2
Molecular Formula	C17H27ClN2O2
Molecular Weight	326.86 g/mol
Synonyms	(R)-1-Boc-2-Benzyl-4-methylpiperazine hydrochloride; (R)-tert-Butyl 2-benzyl-4-methylpiperazine-1-carboxylate HCl; (R)-2-Benzyl-4-methyl-1-(tert-butoxycarbonyl)piperazine hydrochloride; (R)-1-N-Boc-2-benzyl-4-methylpiperazine hydrochloride; (R)-N-Boc-2-benzyl-4-methylpiperazine HCl; (R)-2-Benzyl-4-methylpiperazine-1-carboxylic acid tert-butyl ester hydrochloride; (R)-Boc-2-benzyl-4-methylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-Benzyl-4-Methylpiperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.