Description

(S)-(4-Bromophenyl)(2-(4-Chlorophenyl)Piperazin-1-Yl)Methanone Hydrochloride is a high-purity, chiral piperazine derivative building block of significant interest in advanced pharmaceutical research and development. This compound matters as a critical intermediate for synthesizing novel, targeted therapeutic agents, offering researchers precise control over molecular structure and stereochemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on central nervous system (CNS) targets, receptor modulators, and other innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in early-stage drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity against specific disease targets.
• CNS Drug Development: Serves as a precursor in the research of potential therapeutics for neurological and psychiatric disorders, leveraging the piperazine pharmacophore.
• Chemical Biology Probes: Utilized in the development of selective molecular probes to study enzyme function and receptor interactions in biological systems.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the scalable production of candidate drugs under Good Manufacturing Practice (GMP) guidelines.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis and development services.

Basic Information

Product Name	(S)-(4-Bromophenyl)(2-(4-Chlorophenyl)Piperazin-1-Yl)Methanone Hydrochloride
CAS No.	2132392-81-3
Molecular Formula	C17H17BrClN2O • HCl
Molecular Weight	425.60 g/mol (Free base: 389.69 g/mol)
Synonyms	(S)-4-Bromo-N-[2-(4-chlorophenyl)piperazin-1-yl]benzamide hydrochloride; (S)-1-(4-Bromobenzoyl)-4-(4-chlorophenyl)piperazine hydrochloride; (S)-4'-Bromo-4-chlorophenylpiperazin-1-yl benzophenone hydrochloride; (S)-BPCB hydrochloride; (S)-Enantiomer of 4-Bromo-N-(4-chlorophenylpiperazinyl)benzamide HCl; (S)-Bromochlorophenylpiperazinyl Methanone Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(4-Bromophenyl)(2-(4-Chlorophenyl)Piperazin-1-Yl)Methanone Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing specific results for chiral purity, assay, and impurities are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.