Description

Tm-Dotma is a high-purity, specialized chemical compound used in advanced research and development. This material is critical for applications requiring precise molecular structure and consistent performance, particularly in the pharmaceutical and biotechnology sectors. It is essential for researchers and manufacturers in drug discovery, lipid nanoparticle (LNP) formulation, and advanced material science who require reliable, high-quality building blocks for their innovative processes.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for the development of mRNA delivery systems and other nucleic acid therapeutics.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Gene Therapy Research: Utilized in non-viral vector systems for the encapsulation and targeted delivery of genetic material.
• Bioconjugation & Labeling: Acts as a functionalized linker or tag in the development of diagnostic agents and targeted biomolecules.
• Advanced Material Science: Employed in the creation of specialized polymers, surfactants, and self-assembling nanostructures with unique properties.
• Cosmetic & Dermatological Formulations: Used in the development of advanced delivery systems for active ingredients in skincare products.

Basic Information

Product Name	Tm-Dotma
CAS No.	2126179-30-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,2-Dioleoyl-3-trimethylammonium-propane (chloride salt); DOTMA; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride; CLinDMA; Trimethyl(2,3-bis(oleoyloxy)propyl)ammonium chloride; TM-DOTMA; Cationic lipid DOTMA
EINECS	Contact for details

Quality Control

Every batch of Tm-Dotma is manufactured and tested under strict quality management systems to ensure it meets the high-purity standards required for sensitive pharmaceutical and biotech applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and ensure long-term stability. The material is hygroscopic and must be handled in a dry environment to prevent moisture uptake, which can affect performance. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.