Description

1-Piperidinecarboxylic Acid, 3-Amino-5-Hydroxy-, 1,1-Dimethylethyl Ester, (3R,5R)-Rel- is a high-purity, stereochemically defined chiral building block of significant interest in advanced pharmaceutical synthesis. This compound matters as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing sophisticated piperidine-based scaffolds in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring the (3R,5R) stereochemistry.
• Peptidomimetic Research: Serves as a constrained amino acid analog in the design and synthesis of peptide mimetics for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry: Provides a versatile building block for constructing diverse chemical libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: Potential use in the development of chiral catalysts or ligands for enantioselective transformations.
• Chemical Biology Probe Development: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	1-Piperidinecarboxylic Acid, 3-Amino-5-Hydroxy-, 1,1-Dimethylethyl Ester, (3R,5R)-Rel-
CAS No.	2101332-43-6
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	(3R,5R)-rel-3-Amino-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R,5R)-rel-3-amino-5-hydroxypiperidine-1-carboxylate; (3R,5R)-rel-3-Amino-5-hydroxy-1-Boc-piperidine; 1-Boc-3-amino-5-hydroxypiperidine (rel-(3R,5R)); (R*,R*)-3-Amino-5-hydroxy-1-N-Boc-piperidine; 3-Amino-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester (rel-(3R,5R)); Boc-3-Amino-5-hydroxypiperidine (rel-(3R,5R)); 1-(tert-Butoxycarbonyl)-3-amino-5-hydroxypiperidine (rel-(3R,5R))
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 3-Amino-5-Hydroxy-, 1,1-Dimethylethyl Ester, (3R,5R)-Rel- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (rel-(3R,5R))
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.