Description

tert-Butyl 3',3'-Difluoro-1,4'-bipiperidine-1'-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated bipiperidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily needed by pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas where fluorinated piperidine motifs are advantageous.

Application

• Key Intermediate in Drug Discovery: Serves as a critical building block for the synthesis of potential drug candidates, especially those requiring a fluorinated, conformationally constrained amine moiety.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Synthesis of Bioactive Molecules: Employed in the construction of complex molecules for screening against various biological targets, including G-protein-coupled receptors (GPCRs) and kinases.
• Development of CNS-Active Compounds: The bipiperidine structure is relevant for developing therapeutics for neurological and psychiatric conditions.
• Pre-clinical API Development: Used in the early-stage development and scale-up of active pharmaceutical ingredients (APIs) prior to clinical trials.
• Library Synthesis for High-Throughput Screening: A valuable scaffold for creating diverse chemical libraries to identify new hits in drug discovery campaigns.

Basic Information

Product Name	tert-Butyl 3',3'-Difluoro-1,4'-bipiperidine-1'-carboxylate
CAS No.	2101206-97-5
Molecular Formula	C15H26F2N2O2
Molecular Weight	304.38 g/mol
Synonyms	1,4'-Bipiperidine, 3,3'-difluoro-, 1'-(1,1-dimethylethyl) ester; 1'-Boc-3,3'-difluoro-1,4'-bipiperidine; 3,3'-Difluoro-1,4'-bipiperidine-1'-carboxylic acid tert-butyl ester; tert-Butyl 3,3'-difluoro-[1,4'-bipiperidine]-1'-carboxylate; 1,1-Dimethylethyl 3,3'-difluoro-1,4'-bipiperidine-1'-carboxylate; 3,3'-Difluoro-N-Boc-1,4'-bipiperidine; Boc-3,3'-difluoro-1,4'-bipiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3',3'-Difluoro-1,4'-bipiperidine-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity confirmation, consistent with standards expected for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), identity (by NMR, IR, and MS), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.