Description

Hydroxy-Peg5-Methyl Ester is a high-purity polyethylene glycol (PEG) derivative, specifically a methyl-terminated pentamer with a reactive hydroxyl group. This bifunctional structure is critical for its role as a versatile linker and spacer molecule in advanced chemical synthesis. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and material science industries who require precise control over molecular architecture and hydrophilicity.

Application

• Pharmaceutical Linker: Used in the synthesis of antibody-drug conjugates (ADCs) and prodrugs to improve solubility and pharmacokinetics.
• Bioconjugation Reagent: Serves as a spacer to attach drugs, dyes, or other functional molecules to proteins, peptides, or surfaces.
• Polymer Chemistry Intermediate: A key building block for creating functionalized PEG-based polymers, hydrogels, and surfactants.
• Surface Modification: Employed to PEGylate nanoparticles, quantum dots, and other materials to enhance biocompatibility and reduce immunogenicity.
• Cross-linking Agent: Utilized in the preparation of biodegradable and stimuli-responsive materials for drug delivery systems.
• Research & Development: A valuable tool in medicinal chemistry for structure-activity relationship (SAR) studies and optimizing drug candidates.

Basic Information

Product Name	Hydroxy-Peg5-Methyl Ester
CAS No.	2100306-80-5
Molecular Formula	C13H28O7
Molecular Weight	296.36 g/mol
Synonyms	2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol; 3,6,9,12-Tetraoxatetradecan-1-ol; HO-PEG5-OCH3; PEG5 Monomethyl Ether; mPEG5-OH; 1-Hydroxy-3,6,9,12-tetraoxatetradecane; Methyl-PEG5-alcohol; Polyethylene glycol monomethyl ether (n=5)
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg5-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC)	280 - 310 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.