Description

trans-3,5-Dihydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperidine derivative serving as a critical chiral building block and synthetic intermediate. This compound is essential for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering precise stereochemistry and functional group protection for complex multi-step syntheses. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of biologically active molecules, including potential enzyme inhibitors and receptor modulators.
• Drug Discovery & Development: Used in medicinal chemistry for constructing complex molecular scaffolds during lead optimization and candidate selection.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with specific stereochemical requirements.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or catalysts used in stereoselective transformations.
• Fine Chemical Production: Intermediate in the custom synthesis of specialty chemicals and advanced materials.
• Academic & Contract Research: Utilized in research laboratories for methodological studies and the development of new synthetic routes.

Basic Information

Product Name	trans-3,5-Dihydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	2092515-15-4
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	tert-Butyl trans-3,5-dihydroxypiperidine-1-carboxylate; 1-Boc-3,5-dihydroxypiperidine (trans); trans-1-(tert-Butoxycarbonyl)-3,5-dihydroxypiperidine; trans-3,5-Dihydroxy-1-N-Boc-piperidine; 1-N-Boc-trans-3,5-dihydroxypiperidine; trans-3,5-Piperidinediol, 1-(1,1-dimethylethyl) ester; (3R,5S)- and (3S,5R)-3,5-Dihydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (racemic)
EINECS	Contact for details

Quality Control

Our trans-3,5-Dihydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.