Description

3-Chloro-5-(Trifluoromethyl)Pyrazine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its molecular structure, featuring a reactive nitrile group, a chloro substituent, and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to introduce pyrazine cores with halogen and fluorine motifs into new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Acts as a building block for creating functionalized heterocyclic polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design of molecular probes and activity-based protein profiling (ABPP) agents due to its electrophilic nitrile group.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Pyrazine-2-Carbonitrile
CAS No.	2091672-48-7
Molecular Formula	C6HClF3N3
Molecular Weight	207.54 g/mol
Synonyms	2-Pyrazinecarbonitrile, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-(trifluoromethyl)-2-pyrazinecarbonitrile; 3-Chloro-5-trifluoromethylpyrazine-2-carbonitrile; 2-Cyano-3-chloro-5-trifluoromethylpyrazine; 3-Chloro-5-(trifluoromethyl)pyrazinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(Trifluoromethyl)Pyrazine-2-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.