Description

5H-Pyrrolo[2,3-B]Pyrazine, 2-Chloro-5-[(4-Methylphenyl)Sulfonyl]- is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 2089300-75-2. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Chemical Biology Probes: Serves as a core scaffold for developing tool compounds to study biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical candidates.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	5H-Pyrrolo[2,3-B]Pyrazine, 2-Chloro-5-[(4-Methylphenyl)Sulfonyl]-
CAS No.	2089300-75-2
Molecular Formula	C₁₃H₁₀ClN₃O₂S
Molecular Weight	307.75 g/mol
Synonyms	2-Chloro-5-(p-tolylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine; 2-Chloro-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine; 2-Chloro-5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine; 2089300-75-2; 5H-Pyrrolo[2,3-b]pyrazine, 2-chloro-5-[(4-methylphenyl)sulfonyl]-; 2-Chloro-5-(4-methylphenyl)sulfonyl-5H-pyrrolo[2,3-b]pyrazine
EINECS	Contact for details

Quality Control

Our 5H-Pyrrolo[2,3-B]Pyrazine, 2-Chloro-5-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.