Description

Aminooxy-Peg3-Methyl Ester CAS NO 2086689-03-2 is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group and a methyl ester terminus. This compound is a critical reagent for bioconjugation, enabling the site-specific attachment of biomolecules via oxime bond formation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced drug delivery systems.

Application

• Bioconjugation Reagent: For the site-specific coupling of ketone or aldehyde-containing molecules (e.g., glycoproteins, oxidized carbohydrates) to amine-containing targets via stable oxime linkage.
• Antibody-Drug Conjugate (ADC) Development: Serves as a hydrophilic, biocompatible linker to connect cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• PEGylation Chemistry: Used to introduce a short, flexible PEG spacer to peptides, proteins, or small molecules, improving their stability, solubility, and circulation half-life.
• Surface Functionalization: Modification of nanoparticles, biosensors, or solid supports with aminooxy groups for subsequent immobilization of biomolecules.
• Cross-linking Agent: For creating defined cross-links between different molecular entities in material science and polymer chemistry.
• Proteomics Research: Tool for chemical labeling and enrichment strategies in mass spectrometry-based protein analysis.

Basic Information

Product Name	Aminooxy-Peg3-Methyl Ester
CAS No.	2086689-03-2
Molecular Formula	C12H25NO7
Molecular Weight	295.33 g/mol
Synonyms	3-(2-(2-(2-Aminooxyethoxy)ethoxy)ethoxy)propanoic acid methyl ester; Aminooxy-PEG3-methyl ester; O-(2-Aminoethyl)-O'-(2-carbomethoxyethyl)triethylene glycol; Aminooxy-PEG3-CH2CH2CO2CH3; Methyl 3,6,9-trioxa-12-azaheptadec-16-ynoate (deprecated); Aminooxy functionalized PEG3 methyl ester; Heterobifunctional PEG linker, Aminooxy/ester
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg3-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.